Biomarkers of immune tolerance in liver transplantation
نویسندگان
چکیده
منابع مشابه
Tolerance in liver transplantation: Biomarkers and clinical relevance
Transplantation is the optimal treatment for end-stage organ failure, and modern immunosuppression has allowed important progress in short-term outcomes. However, immunosuppression poorly influences chronic rejection and elicits chronic toxicity in current clinical practice. Thus, a major goal in transplantation is to understand and induce tolerance. It is well established that human regulatory...
متن کاملAnimal Models of Immune Tolerance in Liver Transplantation
Liver transplantation is the most effective treatment for endstage liver diseases with satisfactory clinical results. Unfortunately, adverse effects of life-long immunosuppression prevent the development of alternative strategies to achieve better long-term outcome. Achieving clinical operational tolerance is the ultimate goal in the clinical transplantation field. Around 15% of liver transplan...
متن کاملWorking toward immune tolerance in lung transplantation.
Long-term allograft survival is a major challenge facing solid organ transplantation. Recent studies have shown a negative correlation between infiltration of memory T cells and allograft survival. Furthermore, blockade of leukocyte activation increases acceptance of transplanted organs, including heart, liver, and kidney. Lung allografts are associated with high rates of rejection, and therapi...
متن کاملEffects of combined genes of CTLA4Ig and IDO in post-liver transplantation immune tolerance of rats.
UNLABELLED Background and rationale for the study. Previous studies showed that CTLA4Ig and indoleamine 2,3-dioxygenase (IDO) genes played regulatory role in organ transplantation but failed to reach satisfactory effects. In this study, we constructed an adenovirus- mediated gene expressing CTLA4Ig-IDO and established rat liver transplantation models. Recipients were randomly divided into four...
متن کاملTolerance and chimerism in liver transplantation.
Advances in immunosuppressive therapy have greatly impacted on the successful outcome of organ –and most particularly liver– transplantation. With the introduction of new immunosuppressants the incidence of acute rejection has considerably decreased, and transplanted patient survival is now 83% and 70% after 1 and 5 years, respectively (1). However, toxicity associated with these drugs is signi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Immunology
سال: 2018
ISSN: 0198-8859
DOI: 10.1016/j.humimm.2018.02.010